John B. Hogenesch, Ph.D.

Professor of Pediatrics in the Division of Human Genetics at Cincinnati Children's Hospital Medical Center

Dr. Hogenesch is an Ohio Eminent Scholar and Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center in the Division of Human Genetics. Dr. Hogenesch discovered of Bmal1, the master regulator of the mammalian clock, but also its paralog Bmal2, its partner Npas2, and the positive loop of the clock. Later, his lab characterized Rora/Rorb/Roc as key regulators of Bmal1 and circadian function, discovered Chrono as a non-canonical repressor of Bmal1/Clock, and Kpnb1 as a required transporter of the PER/CRY complex. The Hogenesch lab has led in research into the transcriptional outputs of the clock in animal models and humans. This work is leading to a wealth of new opportunities in circadian medicine and has spurred community contributions, such as the public databases the Gene Atlas and Gene Wiki, CircaDB, and algorithms, including JTK, PSEA, MetaCycle, and CYCLOPS.

Before moving to Cincinnati, Dr. Hogenesch was Professor and Vice Chair of Pharmacology at the University of Pennsylvania Perelman School of Medicine. He received his Ph.D. in Neuroscience at Northwestern University. Currently, Dr. Hogenesch is a Penn Fellow, sits or has sat on the Scientific Advisory Boards of Qiagen, Mimetics, Bio-Rad, the Ryan Licht Sang Foundation Medical Committee, and the Gene Ontology consortium, and is an advisor to several National Institutes of Health, NIDDK, NCI, NHLBI, and the Environmental Protection Agency.