News & Publications

The Clock and Cancer

300% +

increase in the number of publications linking the core clock to cancer in the last 20 years

0

1964-1983

0

1984-2003

+ 0

2004-2021

A History of Clock Research

The clock as a target in cancer therapy
2021
Role of ectopic clock function in progression of glioblastoma stem cells
2019
Michael Young, Michael Rosbash and Jeffrey Hall awarded Nobel Prize for Medicine for their discoveries
2017
Demonstration that, across various tissues, almost half of all genes are governed by the clock
2014
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
2012
The WHO International Agency for Research on Cancer (IARC) classified night-shift work as possibly carcinogenic to humans Reassessed in 2019, reaching the same conclusion
2007
Role of CLOCK in energy balance and metabolism
2005
Genome-wide circadian transcription
2002
Mammalian BMAL1 knocked out
2000
Identification of the clock inhibition feedback loop
1998
Identification of BMAL1 (aka MOP3) as heterodimeric partner of CLOCK
1998
Mammalian CLOCK gene identified. Mammalian Per gene cloned.
1997
Michael Young, Michael Rosbash & Jeffrey Hall labs independently clone the first circadian gene, per, and rescue the mutant phenotype
1984
Ronald Konopka & Seymour Benzer describe the period locus in Drosophila
1971